USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

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Searching in 'USC-OGP 2-DE database' for entry matching: Q16595 USC-OGP 2-DE database:  Q16595 Q16595 General information about the entry View entry in simple text format Entry name FRDA_HUMAN Primary accession number Q16595 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Frataxin, mitochondrial; EC=1.16.3.1; AltName: Full=Friedreich ataxia protein; Short=Fxn; Contains: RecName: Full=Frataxin intermediate form; Short=i-FXN; Contains: RecName: Full=Frataxin(56-210); AltName: Full=m56-FXN; Contains: RecName: Full=Frataxin(78-210); AltName: Full=d-FXN; AltName: Full=m78-FXN; Contains: RecName: Full=Frataxin mature form; AltName: Full=Frataxin(81-210); AltName: Full=m81-FXN; Flags: Precursor;. Gene name Name=FXN Synonyms=FRDA, X25 Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein PLATELET_4-5 {PLATELET 4-5} Homo sapiens (Human)   map experimental info   PLATELET_4-5 MAP LOCATIONS: SPOT OGP-0256: pI=4.80; Mw=15470 Cross-references UniProtKB/Swiss-Prot Q16595; FRDA_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name FRDA_HUMAN Primary accession number Q16595 Secondary accession number(s) A8MXJ6 C9JJ89 O15545 O95656 Q15294 Q5VZ01 Sequence was last modified on  July 15, 1999 (version 2) Annotations were last modified on  March 15, 2017 (version 180) Name and origin of the protein Description RecName: Full=Frataxin, mitochondrial; EC=1.16.3.1; AltName: Full=Friedreich ataxia protein; Short=Fxn; Contains: RecName: Full=Frataxin intermediate form; Short=i-FXN; Contains: RecName: Full=Frataxin(56-210); AltName: Full=m56-FXN; Contains: RecName: Full=Frataxin(78-210); AltName: Full=d-FXN; AltName: Full=m78-FXN; Contains: RecName: Full=Frataxin mature form; AltName: Full=Frataxin(81-210); AltName: Full=m81-FXN; Flags: Precursor; Gene name Name=FXN Synonyms=FRDA, X25 Encoded on Name=FXN; Synonyms=FRDA, X25 Keywords 3D-structure; Alternative splicing; Complete proteome; Cytoplasm; Direct protein sequencing; Disease mutation; Heme biosynthesis; Ion transport; Iron; Iron storage; Iron transport; Metal-binding; Mitochondrion; Oxidoreductase; Polymorphism; Reference proteome; Transit peptide; Transport; Triplet repeat expansion. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL U43747; AAA98510.1; -; mRNA EMBL U43752; AAA98508.1; -; Genomic_DNA EMBL U43748; AAA98508.1; JOINED; Genomic_DNA EMBL U43749; AAA98508.1; JOINED; Genomic_DNA EMBL U43750; AAA98508.1; JOINED; Genomic_DNA EMBL U43751; AAA98508.1; JOINED; Genomic_DNA EMBL U43753; AAA98509.1; -; Genomic_DNA EMBL U43748; AAA98509.1; JOINED; Genomic_DNA EMBL U43749; AAA98509.1; JOINED; Genomic_DNA EMBL U43750; AAA98509.1; JOINED; Genomic_DNA EMBL U43751; AAA98509.1; JOINED; Genomic_DNA EMBL AL162730; CAH71829.1; -; Genomic_DNA EMBL BC023633; AAH23633.1; -; mRNA EMBL BC048097; AAH48097.1; -; mRNA EMBL Y13751; CAA74077.1; -; Genomic_DNA EMBL AF028240; AAB84047.1; -; Genomic_DNA EMBL U93173; AAD00734.1; -; Genomic_DNA CCDS CCDS43834.1; -. [Q16595-3]; . CCDS CCDS55313.1; -. [Q16595-2]; . CCDS CCDS6626.1; -. [Q16595-1]; . RefSeq NP_000135.2; NM_000144.4. [Q16595-1]; . RefSeq NP_001155178.1; NM_001161706.1. [Q16595-2]; . RefSeq NP_852090.1; NM_181425.2. [Q16595-3]; . UniGene Hs.20685; -; . PDB 1EKG; X-ray; 1.80 A; A=86-210 PDB 1LY7; NMR; -; A=91-210 PDB 3S4M; X-ray; 1.30 A; A=82-210 PDB 3S5D; X-ray; 1.50 A; A=82-210 PDB 3S5E; X-ray; 1.31 A; A=82-210 PDB 3S5F; X-ray; 1.50 A; A/B=82-210 PDB 3T3J; X-ray; 1.70 A; A=82-210 PDB 3T3K; X-ray; 1.24 A; A=82-210 PDB 3T3L; X-ray; 1.15 A; A=82-210 PDB 3T3T; X-ray; 1.38 A; A/B/C/D=82-210 PDB 3T3X; X-ray; 1.57 A; A/B=82-210 PDB 5KZ5; EM; 14.30 A; A/B/C/D/E/F/G/H/I/J/K/L=42-210 PDBsum 1EKG; -; . PDBsum 1LY7; -; . PDBsum 3S4M; -; . PDBsum 3S5D; -; . PDBsum 3S5E; -; . PDBsum 3S5F; -; . PDBsum 3T3J; -; . PDBsum 3T3K; -; . PDBsum 3T3L; -; . PDBsum 3T3T; -; . PDBsum 3T3X; -; . PDBsum 5KZ5; -; . DisProt DP00607; -; . ProteinModelPortal Q16595; -; . SMR Q16595; -; . BioGrid 108677; 4; . IntAct Q16595; 6; . MINT MINT-2856590; -; . STRING 9606.ENSP00000366482; -; . ChEMBL CHEMBL2321640; -; . TCDB 9.B.21.1.1; the frataxin (frataxin) family; . iPTMnet Q16595; -; . PhosphoSitePlus Q16595; -; . BioMuta FXN; -; . OGP Q16595; -; . EPD Q16595; -; . MaxQB Q16595; -; . PaxDb Q16595; -; . PeptideAtlas Q16595; -; . PRIDE Q16595; -; . TopDownProteomics Q16595-1; -. [Q16595-1]; . TopDownProteomics Q16595-2; -. [Q16595-2]; . DNASU 2395; -; . Ensembl ENST00000377270; ENSP00000366482; ENSG00000165060. [Q16595-1]; . Ensembl ENST00000396364; ENSP00000379650; ENSG00000165060. [Q16595-2]; . Ensembl ENST00000396366; ENSP00000379652; ENSG00000165060. [Q16595-3]; . GeneID 2395; -; . KEGG hsa:2395; -; . UCSC uc004agz.3; human. [Q16595-1]; . CTD 2395; -; . DisGeNET 2395; -; . GeneCards FXN; -; . GeneReviews FXN; -; . HGNC HGNC:3951; FXN; . HPA CAB022164; -; . HPA HPA068304; -; . MalaCards FXN; -; . MIM 229300; phenotype; . MIM 606829; gene; . neXtProt NX_Q16595; -; . OpenTargets ENSG00000165060; -; . Orphanet 95; Friedreich ataxia; . PharmGKB PA28369; -; . eggNOG KOG3413; Eukaryota; . eggNOG COG1965; LUCA; . GeneTree ENSGT00390000005811; -; . HOGENOM HOG000190729; -; . HOVERGEN HBG005745; -; . InParanoid Q16595; -; . KO K19054; -; . OMA QSVYLMN; -; . OrthoDB EOG091G0UR5; -; . PhylomeDB Q16595; -; . TreeFam TF318958; -; . Reactome R-HSA-1268020; Mitochondrial protein import; . Reactome R-HSA-1362409; Mitochondrial iron-sulfur cluster biogenesis; . ChiTaRS FXN; human; . EvolutionaryTrace Q16595; -; . GeneWiki Frataxin; -; . GenomeRNAi 2395; -; . PRO PR:Q16595; -; . Proteomes UP000005640; Chromosome 9; . Bgee ENSG00000165060; -; . CleanEx HS_FXN; -; . ExpressionAtlas Q16595; baseline and differential; . Genevisible Q16595; HS; . GO GO:0005829; C:cytosol; IDA:BHF-UCL; . GO GO:0005759; C:mitochondrial matrix; ISS:BHF-UCL; . GO GO:0005739; C:mitochondrion; IDA:BHF-UCL; . GO GO:0051537; F:2 iron; 2 sulfur cluster binding; IDA:BHF-UCL GO GO:0008199; F:ferric iron binding; IDA:BHF-UCL; . GO GO:0008198; F:ferrous iron binding; IDA:BHF-UCL; . GO GO:0004322; F:ferroxidase activity; IDA:UniProtKB; . GO GO:0034986; F:iron chaperone activity; IDA:BHF-UCL; . GO GO:0051536; F:iron-sulfur cluster binding; IDA:BHF-UCL; . GO GO:0007628; P:adult walking behavior; IEA:Ensembl; . GO GO:0009060; P:aerobic respiration; IEA:Ensembl; . GO GO:0006879; P:cellular iron ion homeostasis; IMP:BHF-UCL; . GO GO:0070301; P:cellular response to hydrogen peroxide; IDA:UniProtKB; . GO GO:0009792; P:embryo development ending in birth or egg hatching; IEA:Ensembl; . GO GO:0006783; P:heme biosynthetic process; NAS:BHF-UCL; . GO GO:0006811; P:ion transport; IEA:UniProtKB-KW; . GO GO:0018283; P:iron incorporation into metallo-sulfur cluster; IDA:BHF-UCL; . GO GO:0007005; P:mitochondrion organization; IEA:Ensembl; . GO GO:0043066; P:negative regulation of apoptotic process; IMP:UniProtKB; . GO GO:0040015; P:negative regulation of multicellular organism growth; IEA:Ensembl; . GO GO:0046621; P:negative regulation of organ growth; IEA:Ensembl; . GO GO:0090201; P:negative regulation of release of cytochrome c from mitochondria; IMP:UniProtKB; . GO GO:0006119; P:oxidative phosphorylation; IEA:Ensembl; . GO GO:1904234; P:positive regulation of aconitate hydratase activity; IMP:BHF-UCL; . GO GO:0043085; P:positive regulation of catalytic activity; IMP:BHF-UCL; . GO GO:0030307; P:positive regulation of cell growth; IMP:BHF-UCL; . GO GO:0008284; P:positive regulation of cell proliferation; IMP:BHF-UCL; . GO GO:0051349; P:positive regulation of lyase activity; IDA:UniProtKB; . GO GO:1904231; P:positive regulation of succinate dehydrogenase activity; IMP:BHF-UCL; . GO GO:0019230; P:proprioception; IEA:Ensembl; . GO GO:0016540; P:protein autoprocessing; IDA:BHF-UCL; . GO GO:0010722; P:regulation of ferrochelatase activity; IDA:BHF-UCL; . GO GO:0010039; P:response to iron ion; IMP:BHF-UCL; . GO GO:0044281; P:small molecule metabolic process; TAS:Reactome; . Gene3D 3.30.920.10; -; 1; . InterPro IPR017789; Frataxin; . InterPro IPR002908; Frataxin/CyaY; . InterPro IPR020895; Frataxin_CS; . PANTHER PTHR16821; PTHR16821; 1; . Pfam PF01491; Frataxin_Cyay; 1; . PRINTS PR00904; FRATAXIN; . SMART SM01219; Frataxin_Cyay; 1; . SUPFAM SSF55387; SSF55387; 1; . TIGRFAMs TIGR03421; FeS_CyaY; 1; . TIGRFAMs TIGR03422; mito_frataxin; 1; . PROSITE PS01344; FRATAXIN_1; 1; . PROSITE PS50810; FRATAXIN_2; 1; .

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